Proteins are generally broken down1

Proteins are generally broken down1 - single-pass proteins...

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Proteins are generally broken down into the smaller classifications of integral proteins, peripheral proteins, and lipid-bound proteins. Integral Proteins Integral proteins are embedded within the lipid bilayer. They cannot easily be removed from the cell membrane without the use of harsh detergents that destroy the lipid bilayer. Integral proteins float rather freely within the bilayer, much like oceans in the sea. In addition, integral proteins are usually transmembrane proteins, extending through the lipid bilayer so that one end contacts the interior of the cell and the other touches the exterior. The stretch of the integral protein within the hydrophobic interior of the bilayer is also hydrophobic, made up of non-polar amino acids. Like the lipid bilayer, the exposed ends of the integral protein are hydrophilic. When a protein crosses the lipid bilayer it adopts an alpha-helical configuration. Transmembrane proteins can either cross the lipid bilayer one or multiple times. The former are referred to as
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Unformatted text preview: single-pass proteins and the later as multi-pass proteins. As a result of their structure, transmembrane proteins are the only class of proteins that can perform functions both inside and outside of the cell. Peripheral Proteins Peripheral proteins are attached to the exterior of the lipid bilayer. They are easily separable from the lipid bilayer, able to be removed without harming the bilayer in any way. Peripheral proteins are less mobile within the lipid bilayer. Lipid-Bound Proteins Lipid-bound proteins are located entirely within the boundaries of the lipid bilayer. The Cell Surface The protein and lipid cell membrane is covered with a layer of carbohydrate chains on its outer surface. This layer is called a cell coat or glycocalyx. The exact composition and distribution of these chains is very diverse. The chains are thought to provide the cell with protection against damage. Glycocalyx are only found on the surface of the cells of higher organism's....
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This note was uploaded on 12/25/2011 for the course BIO 1421 taught by Professor Farr during the Fall '08 term at Texas State.

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Proteins are generally broken down1 - single-pass proteins...

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