14 - Corynebacterium diphtheriae Corynebacterium...

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Unformatted text preview: Corynebacterium diphtheriae Corynebacterium diphtheriae Biological Features Biological Features Aerobic, Gram + , Noncapsulated, rods Gray-black colonies on tellurite medium Metachromatic granules Chinese-letter morphology in Gram stain Transmission and Transmission and Risk factors Risk factors solely among humans spread by droplets secretions direct contact Poor nutrition Crowded or unsanitary living conditions Low vaccine coverage among infants and children Immunity gaps in adults Pathogenesis of diphtheria Pathogenesis of diphtheria Early stages: Sore throat. Low fever. Swollen neck glands. Late stages: Airway obstruction and breathing difficulty. Shock Diphtheria Toxin (DT) Diphtheria Toxin (DT) Cleaved to yield A/B fragment, joined by S-S bond- A (catalytic domain) - B (transmembrane and receptor binding domains) Receptor : heparin-binding epidermal growth factor - rich on cardiac cells and nerve cells Toxin diffuses throughout body via blood- Cardiac, neurologic complications- Heart/respiratory damage, paralysis...
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This note was uploaded on 12/27/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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14 - Corynebacterium diphtheriae Corynebacterium...

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