32 - Fever marked bleeding tendency Lower blood pressure...

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Hemorrhogic Fever Virus Dept. of microbiology and parasitology Hantaar Virus or HEMORRHAGIC FEVER with renal syndrome virus ( HFRS ) Xing Jiang Hemorrhogic Fever Virus
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Hantaar Virus ( HEMORRHAGIC FEVER with renal syndrome virus )
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Spherical, 80-120nm Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'), RNA polymerase ('L') Envelope: 2 glycoproteins, G1 and G2, Morphology
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Biological properties 1. ssRNA with long, medium,short segments 2. Antigens 6 serotypes (I- VI) 3. Resistance: weak
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Epidemiology 1. Natural host : rodents (deer mouse ( Peromyscus maniculatus ), cotton rat ( Sigmodon hispidus ), marsh rice rat ( Oryzomys palustris ) , white-footed mouse ( Peromyscus leucopus ), other carriers) 2. Transmission : Droplet and rodent excreta spread 3. Season and district
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Clinical syndromes Headache; Pink in face , neck
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Unformatted text preview: Fever marked bleeding tendency Lower blood pressure Urine with Protein multi-organ failure Pathogenicity Clinical manifestations: 5 phases Fever phase Hypotension phase Auria phase Polyuria phase convalescent phase Pathogenesis Viral direct damage Immunopathogenesis Laboratory diagnosis Cultivation: Vero-E6 cell and A549 cell Serological diagnosis: IgM/IgG indirect immunofluorescent assay ELISA-IgM Inactivated vaccine Xing Jiang Hemorrhogic Fever Virus Spherical, 80-120nm Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'), RNA polymerase ('L') Envelope: 2 glycoproteins, G1 and G2, Vector and Host Animal Host Hyalomma asiaticum Season: April and May Inactivated vaccine...
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This note was uploaded on 12/27/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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32 - Fever marked bleeding tendency Lower blood pressure...

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