33 - HERPESVIRUSES HERPESVIRUSES Properties of...

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Unformatted text preview: HERPESVIRUSES HERPESVIRUSES Properties of herpesviruses Properties of herpesviruses Enveloped double stranded DNA viruses. Genome consisits of long and short fragments which may be orientated in either direction, giving a total of 4 isomers. Three subfamilies: – Alphaherpesviruses - HSV-1, HSV-2, VZV – Betaherpesviruses - CMV, HHV-6, HHV-7 – Gammaherpesviruses - EBV, HHV-8 Set up latent or persistent infection following primary infection Reactivation are more likely to take place during periods of immunosuppression Both primary infection and reactivation are likely to be more serious in immunocompromised patients. Herpesvirus Herpesvirus Size: 180-200nm Replication: Nuclear. Assembly: Nuclear. Envelope: Present; associated glycoproteins . Tegument: Protein-filled region between capsid and envelope. Capsid: Icosahedral, 95-105nm diameter; 162 hexagonal capsomers. Core : DNA around protein , ~75nm Genome: Linear, d/s DNA, 105-235kbp Common Antigens: None Herpes viruses can replicate in human diploid cells except of BBV Produce cytopathic effect(CPE) Intranuclear acidophilic inclusion bodies Categories of herpes virus Categories of herpes virus 正正正正 正正正 正正正正 正正正正正正正 正正正正 人人人人人人 1 人人 HHV- 1 人 人人人人人人 1 人人 HSV-1 人 α 人人人人人人人人人人人人人人人人人人 人人人人人人人人人人人人人人人人人 人人人人人人 2 人人 HHV- 2 人 人人人人人人 2 人人 HSV-2 人 α 人人 人人人人人人人人人人人 人人人人人人 3 人人 HHV- 3 人 人人 - 人人人人人人人 VZV 人 α 人人 人人人人人人人人人人 人人人人人人 4 人人 HHV- 4 人 Epstein-Barr 人人 人 EBV 人 γ 人人人人人人人人人人 人人人人人人人人人人人 Burkitt 人人人人人人人人 ? 人人 人人人人人人 5 人人 HHV- 5 人 人人人人人人人 β 人人人人人人人人人人人人人人人人人 人人人人人人人人人人人人人人人人人人人人人人人人人人人人人人人人人 人人人人人人 6 人人 HHV- 6 人 人人人人人人 6 人 β 人人人人人人人 人人人人人人人人人人人人人人人 人人人人人人 7 人人 HHV- 7 人 人人人人人人 7 人 β 人人人人人人人 人人人 人人人人人人 8 人人 HHV- 8 人 人人人人人人 8 人 γ 人 EB 人人 Kaposi 人人 人人人人人人 1 人人 B 人人 α 人 HSV 人人人人人人人人人 1 1 Herpes Simplex Herpes Simplex Viruses Viruses Properties Properties Belong to the alphaherpesvirus subfamily of herpesviruses ds DNA enveloped virus with a genome of around 150 kb The genome of HSV-1 and HSV-2 share 50 - 70% homology....
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33 - HERPESVIRUSES HERPESVIRUSES Properties of...

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