Chapter Hypersensitivity Reactions

Chapter Hypersensitivity Reactions - For more presentations

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Unformatted text preview: For more presentations www.medicalppt.blogspo Hypersensitivity Hypersensitivity Dr.Dilip Dave Dr.Dilip Dave M.D. (Path & Bact) M.D. (Path & Bact) published by published by www.medicalppt.blogspot.com www.medicalppt.blogspot.com For more presentations www.medicalppt.blogspo Definitions Overview of Antigen,Antibody & Cells of immune system Types of hypersensitivity Patho-physiology of each type Examples For more presentations www.medicalppt.blogspo Definition Definition A state of Inappropriate exaggerated response of immune system to an antigen is referred as Hypersensitivity For more presentations www.medicalppt.blogspo Antigen (Ag): A molecule, usually protein in nature, which elicits a specific immune response when introduced into tissue. More specifically, antigenic (immunogenic) substances are: Generally large molecules (>10,000 daltons in molecular weight), Structurally complex (proteins are usually very antigenic), Accessible (the immune system must be able to contact the molecule), and Foreign (not recognizable as "self"). For more presentations www.medicalppt.blogspo Antibody (Ab): A glycoprotein produced in response to an antigen that is specific for the antigen and binds to it via non-covalent interactions. The term "immunoglobulin" is often used interchangeably with "antibody". We will use the term "immunoglobulin" to describe any antibody, regardless of specificity, and the term "antibody" to describe an antigen-specific "immunoglobulin". Immunoglobulins (Igs) come in different forms (IgA, IgD, IgE, IgG, IgM) that reflect their structure. For more presentations www.medicalppt.blogspo Nature of Antibodies.. Nature of Antibodies.. IMMUNOGLOBULINS in 1964 by WHO Proteins of animal origin endowed with known antibody activity and certain other proteins related to them by chemical structure. Immunoglobulin denotes chemical structure. Antibody denotes biological activity and function. For more presentations www.medicalppt.blogspo Antibodies Antibodies Role of Antibodies in health and disease:- a) Elimination of foreign Ag from circulation b) Recruitment and enhancement of host effector mechanisms c) Measurement of sp. Ab level for diagnosis d) Passive immunisation for therapy OR protection For more presentations www.medicalppt.blogspo . . For more presentations www.medicalppt.blogspo Structure of Immunoglobulins Structure of Immunoglobulins Igs are inverted Y-shaped glycoproteins, each molecule containing two polypeptide chains of different sizes. Smaller chains are called light chains, (L) the larger ones are heavy chains. (H) H & L chains are held together by a disulphide bond....
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Chapter Hypersensitivity Reactions - For more presentations

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