renal-cell-carcinoma

renal-cell-carcinoma - RENAL CELL CARCINOMA GENETIC BASIS...

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Unformatted text preview: RENAL CELL CARCINOMA GENETIC BASIS BACKGROUND 3% of adult malignancies 90-95% of neoplasms arising from the kidney [tissue of origin - proximal renal tubular epithelium ] Lack of early warning signs, diverse clinical manifestations Resistance to radiation and chemotherapy, infrequent but reproducible responses to immunotherapy viz. IFN-alpha and IL-2 Targeted therapy [anti angiogenic] Genetics structural alterations of ch.3p tumor suppressors ( VHL, TSC ) or oncogenes ( MET ) 4 hereditary syndromes associated: 1. von Hippel-Lindau (VHL) syndrome, 2. hereditary papillary renal carcinoma (HPRC), 3. familial renal oncocytoma (FRO) associated with Birt-Hogg-Dube syndrome (BHDS), and 4. hereditary renal carcinoma (HRC). von Hippel-Lindau syndrome Autosomal dominant Multiple cancers RCC in nearly 40% of patients del (3p) or t (3;6) or t (3;8) => VHL gene (3p26-p25) mutated => accumulation of hypoxia inducible factors (HIFs) that stimulate angiogenesis through VEGF and VEGFR Hereditary papillary renal...
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renal-cell-carcinoma - RENAL CELL CARCINOMA GENETIC BASIS...

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