Electricity in the Body: NervesTypical nerve cell: –Cell body: genetic control and energy managementDendrites: input of chemical stimuli across synapses––Axon: propagation of the electrical stimulus09/22/20112Lecture 8
Simplified electric modelMembrane is a dielectric insulator (κ≈9) contains: –Na+channelsbodyaxon–K+channels–Na+-K+pumpshihiltf3N+td 2K+itf7membrane3.610 mCQ+QERSphysio-chemical pump: transfers 3Naout and 2Kin per transfer, leaving the cell inside at –70 mV with respect to the outside ++++++membraneVE–Q36cross section fE=0++++–––––––E~7 nmmembraned70 mVSchematic diagram of an ion hl (++)of axon0E=0+++–––––––7 nm10 MV/m2channel (Naor K):1.4-6 homologous repeat domains, 2. outer vestibule,hihlifl++++–––09/22/20113Lecture 82.outer vestibule,3. selectivity filter,5. phosphorylation site,6. membranewhen an ion channel opens, ions flow from the side with the higher concen-trationto the side with the lowest
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