Ch10 - 9/27/2011 1 Molecular Genetics and Regulation...

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Unformatted text preview: 9/27/2011 1 Molecular Genetics and Regulation Chapter 10 Figure 10-0 Molecular Regulation 9/27/2011 2 Points of Gene Regulation Enzyme Pathway Regulation 1. Allosteric Inhibitors and Activators 2. Covalent Modification 9/27/2011 3 Gene Regulatory Proteins in Bacteria Helix-Turn-Helix Motif Prokaryote vs Eukaryote Regulatory Proteins 9/27/2011 4 2 Scenarios For Regulation Difference Between Induction and Derepression 9/27/2011 5 Activation Two Component Signal Transduction Sensing the Environment Signal Transduction Two?? 9/27/2011 6 The Early Pioneers: Lactose Operon Jacques Monod Franois Jacob Andr Lwoff Shared Nobel Prize, Physiology and Medicine, 1965 The Lac Operon 9/27/2011 7 Figure 10-5 Transcriptional induction of the lactose operon. What is Allolactose ? 1,4 1,6 glycosidic bond 9/27/2011 8 Figure 10-7 Regulatory protein interactions with DNA at the lacZYA control region. Figure 10-8 Activation of the lacZYA operon by cAMP and CRP. 9/27/2011 9 Figure 10-9 CRP interactions with RNA polymerase. What About Glucose? -galactosidase: lactose galactose and glucose Glucose produced in the cytoplasm glycolysis + Galactose in the cytoplasm glucose glycolysis + So what about adding lactose + glucose on the outside ? 9/27/2011...
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This note was uploaded on 12/28/2011 for the course MCB 3020 taught by Professor Staff during the Fall '08 term at FIU.

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Ch10 - 9/27/2011 1 Molecular Genetics and Regulation...

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