Ch23 - 10/26/2011 Host Symbiont Relationships Chapter 23...

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10/26/2011 1 Host Symbiont Relationships Chapter 23 Figure 23-0 Human microbiota and nonspecific host defenses . Brain cells, stained with anti-TLR Ab-Alexa 568 (red fluorescence) Anti-Borrelia burgdorfi – fluroescein Anti-brain Ab-Alexa 633 (blue fluorescence) Nuclei color grey-white. Uninfected cells stain blue, infected red.
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10/26/2011 2 Text: 12 year old Girl and 66 year old Man…both with skin cuts swim in Gulf of Mexico Both were infected with Vibrio vulnificus • Both were infected with . • 4 days later: Girl in fine, the Man is dead. • The man: alcoholic with liver The man: alcoholic with liver disease…had poor innate immunity. Symbioses Loose Association vs Tight Facultative vs Obligate Mutualistic both partners benefit Mutualistic - both partners benefit. Commensal – one obviously benefits with no harm to the other. Parasitic – one obviously benefits at the expense of the other (harm to one).
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10/26/2011 3 We have lots of Commensals Our Commensals are Largely Anaerobes
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10/26/2011 4 Human Skin Where’s the Bacteria ?? After all there are 10 12 on the average human: where?. ... 10 4 to 10 6 bacteria/sweat gland Histological Section of Human Skin
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10/26/2011 5 What is in Sweat? Much the same small molecules as in blood, but a lower concentrations: glucose amino acids vitamins fatty acids urea HCO 3 - Na + , K + , Mg ++ , Ca ++ , other minerals. Do the concentrations change? Propionibacterium acnes
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6 The Eye and Lacrimal (Tear) Glands Are the Bacteria: Transient or Resident or Dead ? Resident:
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This note was uploaded on 12/28/2011 for the course MCB 3020 taught by Professor Staff during the Fall '08 term at FIU.

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Ch23 - 10/26/2011 Host Symbiont Relationships Chapter 23...

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