Ch27-28

Ch27-28 - 4/14/2010 AntimicrobialChemotherapy and

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4/14/2010 1 Antimicrobial Chemotherapy and Clinical Microbiology Epidemiology Chapter 27 + 28 Streptomyces avermitilis Produces avermectins (anti parasitic molecules used in veterinary diseases) – contains 7,574 ORFs and undiscovered (worked out) 2 nd ary Metabolic Pathways Alexander Flemming and Penicillin Howard Florey, Purified Penicillin, 1941 One of the First Patients Treated with Penicillin, 1942 Panels 1+2 on admission to hospital and treatment with penicillin. Panel 3: 4 days later Panel 4: 9 days later Panels 5+6 Full recovery
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4/14/2010 2 Gerhard Domagk and Sulfa Drugs Discovered in 1935 Selman Waksman Streptomycin Discovered in 1945 Antibiotic Spectra Testing Antibiotics–MIC’s
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4/14/2010 3 Testing Antibiotics–E strips On Agar Plates Testing Antibiotics–Kirby Bauer S. aureus S. aureus MRSA WRONG–these are μ g/disk MIC’s Are Important
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4/14/2010 4 Antibiotic Modes of Action Cell Wall Synthesis and Antibiotics Beta Lactam Antibiotics Generations of Cephalosporin Each generation: greater spectrum, more effective against antibiotic resistant strains. And, more complex chemical structure. Here generations 1 to 4.
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This note was uploaded on 12/28/2011 for the course MCB 3020 taught by Professor Staff during the Fall '08 term at FIU.

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Ch27-28 - 4/14/2010 AntimicrobialChemotherapy and

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