Glycolysis - PEP TCA Cycle More energy Entry of galactose...

Info iconThis preview shows pages 1–28. Sign up to view the full content.

View Full Document Right Arrow Icon
Glycolysis Chapter 16.1-16.2 The first stages of metabolizing sugars anaerobically
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The Glycolytic pathway splits a six carbon sugar into two 3-carbon compounds It is common to almost all organisms
Background image of page 2
Glycolysis consists of three stages I II III
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Hexokinase uses Induced Fit
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Preparing for the split
Background image of page 6
Aldolase is the enzyme that cleaves the critical bond
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
II III
Background image of page 8
Triose phosphate isomerase (TIM) TIM-barrel α,β- Barrel Very stable and common
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
TIM Mechanism
Background image of page 10
Stage III is Productive! No gain of energy Here is the reward! (2 ATP) x 2 + 2 NADH – 2 ATP
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
II III
Background image of page 12
Glyceraldehyde-3-P Dehyrogenase This uses the favorable oxidation of an aldehyde to an acid to obtain NADH and a high energy phosphate
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Glyceraldehyde 3- phosphate dehydrogenase oxidizes and phosphorylates in one step
Background image of page 14
- 12 kcal/mol + 12 kcal/mol
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
II III
Background image of page 16
Squeezing out one last ATP molecule PEP
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Squeezing out one last ATP molecule
Background image of page 18
Background image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 20
Background image of page 21

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 22
Background image of page 23

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 24
Background image of page 25

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 26
Background image of page 27

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 28
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: PEP TCA Cycle More energy Entry of galactose and fructose into the glycolytic pathway The energy charge of a cell regulates catabolic and anabolic reactions Energy Charge = [ATP] +1/2[ADP] [ATP]+[ADP]+[AMP ] Normal energy charge Adenylate kinase AMP+ATP <=> ADP+ADP Regulation of phosphofructokinase is key to regulating glycolysis Regulation of phosphofructokinase is key to regulating glycolysis Regulation of Glycolysis Glycolysis Regulation Regulation of Pyruvate Kinase: Allosteric and covalent modification (16.2) Allosteric Allosteric Phosphorylation Phosphorylation Glycolysis Glycolysis - Summary Common to most organisms NADH must be converted to NAD + by various means Glycolysis is tightly regulated in multiple ways Regulation is at irreversible steps...
View Full Document

This note was uploaded on 04/06/2008 for the course BIOLCHEM 415/515 taught by Professor Ballou during the Winter '08 term at University of Michigan.

Page1 / 28

Glycolysis - PEP TCA Cycle More energy Entry of galactose...

This preview shows document pages 1 - 28. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online