Core promoter element (e.g. TATA box) Upstream elements Enhancers/silencers Regulatory elements General pattern of regulatory sequences that control gene expression To review what we talked about (cont.): Class II promoters (promoter regions) have two parts
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Tissue specificity of regulatory (cis) elements DNA is the same in every cell/tissue of the organism the very same cis elements (including enhancers)are present in each tissue Tissue specificity is due to either presence or absence of particular regulatory (=binding) protein(s), also known as transcription factors (TFs) Regulatory proteins are tissue specific Regulatory proteins dictate tissue specificity of ciselements; very important at the level of initiation of transcription Enhancer Promoter Control elements Albumin gene Crystallin gene Liver cell nucleus Lens cell nucleus Available activators Available activators Albumin gene expressed Albumin gene not expressed Crystallin gene not expressed Crystallin gene expressed Liver cell Lens cell