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Unformatted text preview: the mutant to slower (but still in increase in rate) in the newly engineered protein First Paragraph: • Combine experiments with MD simulations of protein folding o Improvement in time resolution for kinetic folding studies Nanosecond optical triggering methods Distributed computing • Can directly MD simulations with experiements on ultrafast folding proteins • Why important: if accurate, contain complete atomic description of the folding mechanism • Computational cost small size and ultrafast folding • HP35 o Subdomain of the headpiece of villin (actin binding protein) o Smallest naturally occurring polypeptide that folds autonomously without any cofactor or disulfide bond Thermostable Globular Hydrophobic core o Resembles...
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This note was uploaded on 12/24/2011 for the course BB 481 taught by Professor Staff during the Spring '11 term at Oregon State.
- Spring '11