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Unformatted text preview: • Moving From the Ethnographic… • Juxtaposing the Personal with the Scientific • “Amazing Brains” • The donation and arrival of the nuns brains to Markesbery’s laboratory marks an important methodological shift in the “Nun Study” • Shift from the ethnographic to the science of pathology and the physical evidence attributed to Alzheimer’s disease • Pathology 101 • New Research Question • How the pathology in the brain relates to the expression of the symptoms of Alzheimer’s? • Illuminating Relationships… • “Illuminating the relationship between the symptoms of the disease – the progressive, devastating loss of function – and the damage to the brain that causes those symptoms…” • Brain Autopsies • Alzheimer’s disease can only truly be ascertained upon brain autopsies • The two most common features of an Alzheimer’s brain are the plaques and tangles • Gross examination (naked eye) • Micro examination (aid of a microscope) • Paradigm Shift I • What are the Laboratory Procedures? • Braak Scale!! • Braak Stages… • Stages I and II: spread of tangles near the base of the skull – important for memory • Stages III and IV: spread of tangles higher and deeper in the brain - hippocampus – critical to learning and memory • Stages V and VI: tangles reach upper top layer of the brain – neocortex – orients us in time, interpretation and expression of language...
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- Winter '10