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Unformatted text preview: Moving From the Ethnographic Juxtaposing the Personal with the Scientific Amazing Brains The donation and arrival of the nuns brains to Markesberys laboratory marks an important methodological shift in the Nun Study Shift from the ethnographic to the science of pathology and the physical evidence attributed to Alzheimers disease Pathology 101 New Research Question How the pathology in the brain relates to the expression of the symptoms of Alzheimers? Illuminating Relationships Illuminating the relationship between the symptoms of the disease the progressive, devastating loss of function and the damage to the brain that causes those symptoms Brain Autopsies Alzheimers disease can only truly be ascertained upon brain autopsies The two most common features of an Alzheimers brain are the plaques and tangles Gross examination (naked eye) Micro examination (aid of a microscope) Paradigm Shift I What are the Laboratory Procedures? Braak Scale!! Braak Stages Stages I and II: spread of tangles near the base of the skull important for memory Stages III and IV: spread of tangles higher and deeper in the brain - hippocampus critical to learning and memory Stages V and VI: tangles reach upper top layer of the brain neocortex orients us in time, interpretation and expression of language...
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- Winter '10