MELOXICAM - MELOXICAM Meloxicamum C14H13N3O4S2 P.t.l: 351,4...

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MELOXICAM Meloxicamum C 14 H 13 N 3 O 4 S 2 P.t.l: 351,4 Meloxicam là 4-hydroxy-2-methyl-N-(5methyl-1,3-thiazol-2-yl)-2H-1, 2-benzothiazin-3-carboxamid 1,1- dioxyd, ph i ch a t 99,0 đ n 100,5% C ứ ừ ế 14 H 13 N 3 O 4 S 2 tính theo ch ph m đã làm khô. ế Tính ch t: B t màu vàng nh t, th c t không tan trong n c, khó tan trong aceton, tan trong dimethylformamid, r t ự ế ướ khó tan trong ethanol 96% và methanol. Đ nh tính: A. Ph h ng ngo i (Ph l c 4.2) c a ch ph m ph i phù h p v i ph h ng ngo i đ i chi u c a ổ ồ ụ ụ ế ổ ồ ế meloxicam chu n (ĐC). B. Ph h p th t ngo i (Ph l c 4.1) c a dung d ch ch ph m 0,0015% trong ổ ấ ụ ử ụ ụ ế methanol (TT) d i sóng ở ả t 240 nm đ n 450 nm cho m t c c đ i h p th t i b c sóng 354 nm. Đ h p th b c sóng 354 nm ế ộ ự ạ ấ ụ ạ ướ ộ ấ ụ ở ướ kho ng 0,8. Đ trong c a dung d ch Dung d ch ch ph m 5,0% trong ế dimethyl formamid (TT) ph i trong (Ph l c 9.2). ụ ụ T p ch t liên quan Ti n hành b ng ph ng pháp s c ký l ng (Ph l c 5.3) ế ươ ụ ụ Pha đ ng A : Dung d ch kali dihydro phosphat 0,1%, đã đ c đi u ch nh đ n pH 6,0 b ng ượ ế dung d ch natri hydroxyd 8,5%. Pha đ ng B :
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This note was uploaded on 12/28/2011 for the course PHARMACEUT 101 taught by Professor Yentrang during the Spring '11 term at Albany College of Pharmacy and Health Sciences.

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MELOXICAM - MELOXICAM Meloxicamum C14H13N3O4S2 P.t.l: 351,4...

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