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Atenolol xem lai - ATENOLOL Atenololum v ng phn i quang...

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ATENOLOL Atenololum và đ ng phân đ i quang C 14 H 22 N 2 O 3 P.t.l: 266,3 Atenolol là 2-[4-[(2 RS )-2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamid, ph i ch a t 98,0% đ n 102,0% C ế 14 H 22 N 2 O 3 , tính theo ch ph m đã làm khô. ế Tính ch t B t k t tinh màu tr ng ho c g n nh tr ng, h i tan trong n c, tan trong ethanol, khó tan trong ế ư ơ ướ methylen clorid. Đ nh tính Có th ch n m t trong hai nhóm đ nh tính sau: Nhóm I: A Nhóm II: B, C, D A. Ph h ng ngo i (Ph l c 4.2) c a m u th ph i phù h p v i ph h ng ngo i c a atenolol chu n (ĐC). B. Hòa tan 0,100 g ch ph m trong 100 ml ế methanol (TT) . Pha loãng 10,0 ml dung d ch trên v i methanol (TT) thành 100 ml. Đo ph h p th t ngo i (Ph l c 4.1) t 230 nm đ n 350 nm, dung ụ ử ụ ụ ế d ch có hai c c đ i h p th 275 nm và 282 nm. T s đ h p th c c đ i đo ụ ở 275 nm và 282 nm t 1,15 đ n 1,20. ế C. Đi m ch y: T 152 o C đ n 155 ế o C (Ph l c 6.7) ụ ụ D. S c ký l p m ng (Ph l c 5.4) ụ ụ B n m ng: S ilica gel GF 254 (TT). Dung môi khai tri n: Amoniac – methanol (1 : 99) Dung d ch th : Hòa tan 10 mg ch ph m trong 1 ml ế methanol (TT). Dung d ch đ i chi u: ế Hòa tan 10 mg atenolol chu n (ĐC) trong 1 ml methanol (TT). Cách ti n hành: ế Ch m riêng bi t lên b n m ng 10 μ l m i dung d ch trên. Khai tri n s c ký đ n khi ế dung môi đi đ c kho ng 15 cm. Đ khô b n m
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