Cefuroxim natri - CEFUROXIM NATRI Cefuroximum natricum...

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CEFUROXIM NATRI Cefuroximum natricum C 16 H 15 N 4 NaO 8 S P.t.l: 446,4 Cefuroxim natri là mu i natri c a acid (6 R ,7 R ) -3[(carbamoyloxy)methyl]-7-[[( Z )-(furan-2-yl) (methoxyimino) acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic, ph i ch a t 96,0 đ n 102,0% ế C 16 H 15 N 4 NaO 8 S, tính theo ch ph m ế khan. Tính ch t B t tr ng ho c g n nh tr ng, h i hút m, d tan trong n c, r t khó tan trong ethanol. ư ắ ơ ướ Đ nh tính A. Ph h ng ngo i (Ph l c 4.2) c a ch ph m ph i phù h p v i ph h ng ngo i c a ổ ồ ụ ụ ế ổ ồ ạ ủ cefuroxim natri chu n (ĐC). B. Ch ph m ph i cho ph n ng (A) c a ion natri (Ph l c 8.1). ế ả ứ ụ ụ Đ trong và màu s c c a dung d ch ắ ủ Dung d ch S: Hòa tan 2,0 g ch ph m trong ế n c không có ướ carbon dioxyd (TT) và pha loãng thành 20,0 ml v i cùng dung môi. Dung d ch S không đ c đ c h n h n d ch chu n II (Ph l c 9.2). Đ h p th (Ph l c 4.1) c a ượ ơ ụ ụ ộ ấ ụ ụ dung d ch S đo 450 nm không đ c l n h n 0,25. ượ ớ ơ pH T 5,5 đ n 8,0 (Ph l c 6.2). ế ụ ụ Pha loãng 2 ml dung d ch S thành 20 ml v i n c không có carbon dioxyd ướ (TT) . Góc quay c c riêng
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This note was uploaded on 12/28/2011 for the course PHARMACEUT 101 taught by Professor Yentrang during the Spring '11 term at Albany College of Pharmacy and Health Sciences.

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Cefuroxim natri - CEFUROXIM NATRI Cefuroximum natricum...

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