HALOPERIDOL da xong - HALOPERIDOL Haloperidolum...

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HALOPERIDOL Haloperidolum C 21 H 23 ClFNO 2 P.t.l: 375,9 Haloperidol ph i ch a t 99,0 đ n 101,0% 4-[4-4-clorophenyl)-4-hydroxypiperidin-1-yl]-1-(4- ế fluorophenyl)butan-1-on, tính theo ch ph m đã làm khô. ế Tính ch t B t màu tr ng hay g n nh tr ng. ư Th c t không tan trong n c, ít tan trong ethanol, ế ướ methanol và methylen clorid. Đ nh tính Có th ch n m t trong hai nhóm đ nh tính sau: Nhóm 1: B, E. Nhóm 2: A, C, D, E. B. Ph h ng ngo i (Ph l c 4.2) c a ch ph m ph i phù h p v i ph h ng ngo i c a ế haloperidol chu n (ĐC). Chu n b ch ph m d i d ng đĩa. ế ướ A. Đi m ch y t 150 đ n 153 ế o C (Ph l c 6.7). ụ ụ C.Ph ng pháp s c ký l p m ng (Ph l c 5.4) ươ ụ ụ B n m ng: Octadecylsilyl silica gel. Dung môi khai tri n: Tetrahydrofuran - methanol - dung d ch natri clorid 5,8% (10 : 45 : 45) Dung d ch th : Hòa tan 10 mg ch ph m th trong ế methanol (TT) pha loãng v i methanol (TT) thành 10 ml. Dung d ch đ i chi u (1): ế Hòa tan 10 mg haloperidol chu n (ĐC) trong methanol (TT) và pha loãng thành 10 ml v i cùng dung môi. Dung d ch đ i chi u (2): ế Hòa tan 10 mg haloperidol chu n (ĐC) và 10 mg bromperidol chu n (ĐC) trong methanol (TT) và pha loãng thành 10 ml v i cùng dung môi. Cách ti n hành: ế Ch m riêng bi t lên b n m ng 1 μl c a m i dung d ch trên. Tri n khai s c ký trong bình ch a bão hòa dung môi khai tri n trên m t kho ng dài 15 cm. Đ khô b n m ng ư ngoài không khí và ki m tra d i ánh sáng t ngo i t i b c sóng 254 nm. V
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