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Acid mefenamic - Acid mefenamic Acidum mefenamicum...

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Acid mefenamic Acidum mefenamicum C 15 H 15 NO 2 P.t.l: 241,3 Acid mefenamic là acid 2-[(2,3-dimethylphenyl)amino]benzoic , ph i ch a t 99,0 đ n 100,5% ế C 15 H 15 NO 2 , tính theo ch ph m khan. ế Tính ch t B t vi tinh th màu tr ng hay g n nh tr ng. ư Th c t không tan trong n c, h i tan trong ethanol 96% và trong methylen clorid. D tan trong các ế ướ ơ dung d ch hydroxyd ki m loãng. Có nhi u d ng tinh th . Đ nh tính Có th ch n m t trong hai nhóm đ nh tính sau: Nhóm I: A Nhóm II: B, C, D A. Ph h ng ngo i (Ph l c 4.2) c a ch ph m ph i phù h p v i ph h ng ngo i c a ế acid mefenamic chu n (ĐC). N u ph h ng ngo i c a m u th và m u chu n khác nhau thì hoà tan tách ế bi t ch ph m và ế acid mefanamic chu n (ĐC) trong ethanol 96% (TT) , b c h i đ n khô, ghi ph ơ ế m i các c n thu đ c. ượ B. Hòa tan 20 mg ch ph m trong h n h p ế acid hydrocloric 1 M - methanol (1 : 99) và pha loãng thành 100 ml v i cùng h n h p dung môi. Pha loãng 5 ml dung d ch này thành 50 ml v i m t h n h p acid hydrocloric 1 M - methanol (1 : 99). Đo ph h p th (Ph l c 4.1) c a dung d ch này trong ụ ụ kho ng b c sóng t 250 nm đ n 380 nm. Ph thu đ c có hai c c đ i h p th 279 nm và 350 ướ ế ượ ụ ở nm. T s đ h p th đo b c sóng c c đ i 279 nm so v i 350 nm kho ng t 1,1 đ n 1,3. ỷ ố ướ ớ ở ế C. Hoà tan kho ng 25 mg ch ph m trong 15 ml
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