Metoclopramid - METOCLOPRAMID Metoclopramidum C14H22ClN3O2...

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METOCLOPRAMID Metoclopramidum C 14 H 22 ClN 3 O 2 P.t.l: 299,8 Metoclopramid là 4-amino-5-cloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamid, ph i ch a t 99,0 đ n 101% C ế 14 H 22 ClN 3 O 2 tính theo ch ph m đã làm khô. ế Tính ch t B t m n, đa hình, màu tr ng ho c g n nh tr ng. ư Th c t không tan trong n c, h i tan trong dicloromethan, h i tan đ n khó tan trong ethanol ế ướ ơ ơ ế 96%. Đ nh tính Có th ch n m t trong hai nhóm đ nh tính sau: Nhóm I: A, B Nhóm II: B, C A. Ph h ng ngo i (Ph l c 4.2) c a ch ph m ph i phù h p v i ph h ng ngo i đ i chi u ụ ụ ế ế c a metoclopramid chu n (ĐC) . B. Đi m ch y c a ch ph m ph i t 145 ế o C đ n 149 ế o C (Ph l c 6.7). ụ ụ C. Ti n hành s c ký l p m ng (Ph l c 5.4): V t chính trên s c đ c a dung d ch th (1) ế ụ ụ ế ph n T p ch t liên quan ph i gi ng v v trí, kích th c và màu s c v i v t chính trên s c đ ướ ế c a dung d ch đ i chi u (1). ế Đ trong và màu s c c a dung d ch Hòa tan 2,5 g ch ph m trong 25 ml ế dung d ch acid hydrocloric 1 M (TT) . Dung d ch ph i trong (Ph l c 9.1) và màu không đ m h n màu m u V ụ ụ ơ 6 (Ph l c 9.3, ph ng pháp 2). ụ ụ ươ T p ch t liên quan A. Xác đ nh b ng ph ng pháp s c ký l p m ng (Ph l c 5.4). ươ ụ ụ B n m ng: Silica gel GF 254 (TT).
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