Ethinylestradiol - ETHINYLESTRADIOL Ethinylestradiolum...

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ETHINYLESTRADIOL Ethinylestradiolum C 20 H 24 O 2 P.t.l: 296,4 Ethinylestradiol là 19-Nor-17 (-pregna-1,3,5(10)-trien-20-yn-3,17-diol ph i ch a t 97,0 đ n ế 102,0% C 20 H 24 O 2 tính theo ch ph m đã làm khô. ế Tính ch t B t k t tinh màu tr ng ho c màu tr ng h i vàng. Th c t không tan trong n c, d tan trong ế ơ ế ướ ethanol 96%, tan trong dung d ch ki m loãng. Đ nh tính A. Ph h ng ngo i (Ph l c 4.2) c a ch ph m ph i phù h p v i ph h ế ng ngo i c a ethinylestradiol chu n (ĐC). N u ph h ng ngo i c a chúng khác nhau thì hoà tan ch ph m và ch t đ i chi u trong ế ế ế methanol, b c h i đ n khô và xác đ nh l i ph h ng ngo i c a các c n thu đ c. ơ ế ượ B.S c ký l p m ng (Ph l c 5.4) ụ ụ B n m ng : Silica gel G (TT) Dung môi khai tri n: Ethanol 96% - toluen (10 : 90) Dung d ch th : Hoà tan 25 mg ch ph m trong h n h p ế methanol - methylen clorid (1 : 9) và pha loãng thành 25 ml b ng cùng dung môi. Dung d ch đ i chi u: ế Hoà tan 25 mg ethinylestradiol chu n (ĐC) trong 25 ml h n h p methanol - methylen clorid (1:9) và pha loãng thành 25 ml b ng cùng dung môi. Cách ti n hành: ế Ch m riêng bi t lên b n m ng 5 µl dung d ch đ i chi u và dung d ch th .
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