ISONIAZID - ISONIAZID Isoniazidum C6H7N3O P.t.l: 137,14...

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ISONIAZID Isoniazidum C 6 H 7 N 3 O P.t.l: 137,14 Isoniazid laø pyridin-4-carbohydrazid, phaûi chöùa töø 99,0 ñeán 101,0% C 6 H 7 N 3 O, tính theo cheá phaåm ñaõ laøm khoâ. Tính chaát Boät keát tinh traéng hay tinh theå khoâng maøu, khoâng muøi. Deã tan trong nöôùc, hôi tan trong ethanol 96%, khoù tan trong cloroform, raát khoù tan trong ether. Ñònh tính Coù theå choïn moät trong hai nhoùm ñònh tính sau: Nhoùm I: B vaø C. Nhoùm II: A vaø C. A. Phoå hoàng ngoaïi (Phuï luïc 4.2) cuûa cheá phaåm phaûi phuø hôïp vôùi phoå hoàng ngoaïi cuûa isoniazid chuaån hoaëc phoå hoàng ngoaïi ñoái chieáu cuûa isoniazid chu n (ĐC). B. Hoaø tan 0,1 g cheá phaåm trong 2 ml nöôùc, theâm dung dòch noùng cuûa 0,10 g vanilin (TT) trong 10 ml nöôùc , ñeå yeân vaø coï thaønh oáng nghieäm baèng moät ñuõa thuûy tinh, seõ coù tuûa vaøng, tuûa naøy sau khi keát tinh laïi baèng 5 ml ethanol 70% vaø saáy khoâ ôû 100 – 105 o C, coù ñieåm chaûy töø 226 – 231 o C (Phuï luïc 6.7).
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This note was uploaded on 12/28/2011 for the course PHARMACEUT 101 taught by Professor Yentrang during the Spring '11 term at Albany College of Pharmacy and Health Sciences.

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ISONIAZID - ISONIAZID Isoniazidum C6H7N3O P.t.l: 137,14...

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