ApoptosisCahill - Apoptosis Greek: apo = from ptosis =...

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Apoptosis Greek: apo = from ptosis = falling
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What is Apoptosis? Programmed cell death Natural pruning process Adults: 50-70 billion cells/day Child: 20-30 billion cells/day In one year’s time, the mass of cells which proliferate and destruct is equal to an individual’s weight.
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Apoptosis Maintains Homeostasis Extrinsic Signals: Hormones Cytokines Must cross cell membranes to induce or inhibit apoptosis.
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Apoptosis Maintains Homeostasis Intrinsic Signals: Enzyme release in response to stress via regulatory proteins
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Execution Stimulus received Controls executed Organized degradation by proteolytic caspases Characteristic morphology of cells Cells break apart Phagocytosis by macrophages recycled Recycled w/o inflammatory response
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History 1999 – Dr. Ikonomidou and colleagues described apoptotic neurodegeneration in juvenile rats exposed to NMDA receptor blocking agents.
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History Followed by Drs. Jevtovic-Todorovic,
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ApoptosisCahill - Apoptosis Greek: apo = from ptosis =...

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