cholesterol-1 - Cholesterol Metabolism Sources of...

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Cholesterol Metabolism Sources of cholesterol Cholesterol synthesis Long and short term regulation SREBP-2 Lowering cholesterol Calculating your risk for CHD
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Roles of Cholesterol Membrane component Steroid synthesis Bile acid/salt precursor Vitamin D precursor
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Sources of Cholesterol Diet De novo synthesis Cholesterol synthesized in extrahepatic tissues Liver cholesterol pool Free cholesterol In bile Conversion to bile salts/acids Secretion of HDL and VLDL
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Cholesterol Structure FA for esterification
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Dietary Cholesterol Animal products – eggs Absorb about 50% Increase intake = decreased absorption Excrete – 1 g/day (bile acids)
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Dietary Cholesterol Assume 400 mg intake / day 200 mg is absorbed 1000 mg is excreted 800 mg from de novo synthesis Lowering cholesterol in diet has very little effect on blood cholesterol !!!
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Cholesterol Synthesis Similar to ketogenic pathway Occurs in cytosol Requires NADPH and ATP Highly regulated 80 % in liver, ~10% intestine, ~5% skin
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Cholesterol Synthesis
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