cmws1_6274 - BLOOD COAGULATION: AT THE INTERFACE BETWEEN...

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BLOOD COAGULATION: AT THE INTERFACE BETWEEN PHYSICAL AND CHEMICAL KINETICS
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©2006 UpToDate ®   ©2006 UpToDate ®  •  www.uptodate.com  •  Contact Us     e-mail this to a colleague                                                                                                                              
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©2006 UpToDate ®   ©2006 UpToDate ®  •  www.uptodate.com  •  Contact Us     e-mail this to a colleague                                                                                                               
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FUSTER et al, 2005
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FUSTER et al., 2005
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Local homeostasis maintained by continuous adjustments to changes threshold Tissue PERTURBATION RESPONSE “COAGULATION” Hemostasis thrombophilia hemophilia Disseminated coagulation “INFLAMMATION” Immunity hypersensitivity autoimmunity Immunodeficiency REACTION RATE CHANGE
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PLASMA COAGULATION / FIBRINOLYSIS PROCOAGULANT SURFACES FLOW
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COAGULATION CONTROL INHIBITORS HEPARIN (Glycosaminoglycans) Warfarin (Vit.-K antagonist) Anti-platelets PROCOAGULANTS COAGULATION FACTORS BLOOD TRANSFUSIONS STATINS ? Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A Reduce cholesterol levels and cardiovascular disease but Under the best circumstances 2/3 cardiovascular events remain.
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Contact activator “autoactivation of fXII Pre to kallikrein H-kininogen to bradikinin
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cmws1_6274 - BLOOD COAGULATION: AT THE INTERFACE BETWEEN...

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