ezetimibe - Pathway of Exogenous Cholesterol Metabolism...

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Pathway of Exogenous Cholesterol Metabolism INTESTINAL LUMEN LYMPH BLOOD Chylomicrons BILIARY TRACT Remnants DIET Micelles Free cholesterol Cholesterol Bile acids Unstirred water layer Synthesis FC biosynthesis ACAT Cholesteryl Ester (CE) FC ENTEROCYTE Brush Border Plaque formation CE CE
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Complementary Mechanisms of Action Lead to Broader Lipid Control DIETARY CHOLESTEROL BILIARY SECRETION INTESTINE Excretion VLDL LDL Absorption synthesis IDL Statins Cholesterol Absorption Inhibition
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Inhibition of Cholesterol Absorption
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* p <0.01 vs. placebo Mean % Change in LDL from Baseline at Week 12 0 -5 -10 -15 -20 LDL-C TG Placebo (n=409) Ezetimibe 10 mg (n=1234) Ezetimibe 10 mg (n=1234) 0.3 -17.4* 3.5 -4.2* HDL-C Placebo (n=409) Placebo (n=409) Ezetimibe 10 mg (n=1234) -1.6 1.0* Placebo EZ 10 mg Ezetimibe Ezetimibe Phase III Pooled Monotherapy: Efficacy Results
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Ezetimibe Phase III Monotherapy: Ezetimibe Phase III Monotherapy: Pooled Safety Results Pooled Safety Results Placebo Ezetimibe (n=431) (n=1288) Adverse events
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This note was uploaded on 12/28/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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ezetimibe - Pathway of Exogenous Cholesterol Metabolism...

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