Pentose Phosphate Pathway

Pentose Phosphate Pathway - Pentose Phosphate Pathway...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
    Pentose Phosphate Pathway Generation of NADPH  and Pentoses
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
    Overview Function NADPH production Reducing power  carrier Synthetic pathways Role as cellular  antioxidants Ribose synthesis Nucleic acids and  nucleotides
Background image of page 2
    Characteristics: Tissue Distribution Demand for NADPH Biosynthetic pathways FA synthesis (liver, adipose, mammary) Cholesterol synthesis (liver) Steroid hormone synthesis (adrenal, ovaries, testes) Detoxification (Cytochrome P-450 System) – liver Reduced glutathione as an antioxidant (RBC) Generation of superoxide (neutrophils)
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
    Characteristics: Oxidative and Non-oxidative Phases Oxidative phases Reactions producing  NADPH Irreversible  Non-oxidative phases Produces ribose-5-P Reversible reactions  feed to glycolysis
Background image of page 4
    NADPH producing reactions Glucose-6-P dehydrogenase 6-P-gluconate dehydrogenase
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
    The Pentose Phosphate Pathway: Non-oxidative phases
Background image of page 6
    Regulation Glucose-6-P dehydrogenase First step Rate limiting Allosteric Regulation Feedback inhibited by NADPH Inducible enzyme Induced by insulin
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/28/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

Page1 / 22

Pentose Phosphate Pathway - Pentose Phosphate Pathway...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online