Amino acids and peptides

Amino acids and peptides - Amino acids and peptides The...

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Amino acids and peptides The “Lego” of proteins
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Amino Acids Same general structure Called alpha amino acids L- isomer is physiologically active Side chain or R group determines other properties Acid-base properties H 3 N+ R O O
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Amino Acids, General pK of carboxyl group around 2.3 Deprotonated at physiological pH R – COO - pK of amino group around 9.5 Protonated at physiological pH • H 3 N + -R Some R-groups are acidic or basic
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Nonpolar amino acids NH 3 + C H O CH 3 O NH 3 + C H 2 O O NH 3 + C H 2 C H O C H 3 CH 3 O NH 3 + C H CH 2 O C H 3 C H 3 O N + O O H H glycine(G) Alanine (A) NH 3 + CH 3 O O CH 3 Valine (V) Leucine (L) Isoleucine (I) Proline (P)
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Aromatic Amino Acids H 3 N+ O O H 3 N+ O N O H 3 N+ O O H O phenylalanine (F) tyrosine (Y) pKr = 10 . 07 tryptophan (W)
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Polar Amino Acids, alcohols H 3 N+ O H O O H 3 N+ C H 3 OH O O Serine (S) Threonine (T)
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Polar Amino Acids (sulfur containing) H 3 N+ O S H O N 3 N+ O S C H 3 O Cysteine (C) Methionine (M)
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Polar amino acids (amides) H 3 N+ O O N H 2 O H 3 N+ O O N H 2 O Asparagine (N) Glutamine (Q)
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Charged Amino Acids (Acidic) H 3 N+ O O O O H 3 N+ O O O O Aspartate (D) Glutamate (E) pKr = 3 .
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Amino acids and peptides - Amino acids and peptides The...

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