Kreb's Cycle - Krebs Cycle(aka tricarboxylic acid(TCA)cycle...

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Kreb’s Cycle (aka, tricarboxylic acid (TCA)cycle, citric acid cycle) “The wheel is turnin’ and the sugar’s a burnin’”
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Overall goal Makes ATP Makes NADH Makes FADH 2 Requires some carbohydrate to run Watch for reaction coupling
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Geography Glycolysis in the cytosol Krebs in mitochondrial matrix Mitochondrion Outer membrane very permeable Space between membranes called intermembrane space (clever huh!) Inner membrane (cristae) Permeable to pyruvate, Impermeable to fatty acids, NAD, etc Matrix is inside inner membrane
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Conversion of pyruvate to Acetyl CoA C H 3 O O O pyruvate CO 2 HSCoA C H 3 SCoA O acetyl CoA NADH NAD+ pyruvate dehydrogenase complex 2 per glucose (all of Kreb’s) Oxidative decarboxylation Makes NADH -33.4kJ
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Fates of Acetyl CoA C H 3 SCoA O acetyl CoA Kreb's CO 2 , ATP, NADH. ..energy ketone bodies no CHO present TAG's In the presence of CHO an using energy Metabolized to CO 2 , NADH, FADH 2 ,GTP and, ultimately, ATP If energy not being used (Lots of ATP present) Made into fat If energy being used, but no CHO present Starvation Forms ketone bodies (see fat metabolism slides) Danger!
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Kreb’s Cycle C H 3 C O SCoA acetyl CoA
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Kreb's Cycle - Krebs Cycle(aka tricarboxylic acid(TCA)cycle...

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