Nucleic Acid Chemistry

Nucleic Acid Chemistry - Nucleic Acid Chemistry Where the...

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Nucleic Acid Chemistry Where the info is…interpreting the blueprint
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Central Dogma DNA ---------------- RNA-------------- protein Replication transcription translation
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Central Dogma Replication DNA making a copy of itself Making a replica Transcription DNA being made into RNA Still in nucleotide language Translation RNA being made into protein Change to amino acid language
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Replication Remember that DNA is self complementary Replication is semiconservative One strand goes to next generation Other is new Each strand is a template for the other If one strand is 5’ AGCT 3’ Other is: 3’ TCGA 5’
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Replica Write the strand complementary to: 3’ ACTAGCCTAAGTCG 5’ Answer
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Replication is Semiconservative
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Replication Roles of enzymes Topoisomerases Helicase DNA polymerases ligase DNA binding proteins DNA synthesis Leading strand Lagging strand
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Replication
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Replication Helix opens Helicase Causes supercoiling upstream Topoisomerases (gyrase) DNA Binding Proteins Prevent reannealing
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Replication
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Replication Leading strand 3’ end of template As opens up, DNA polymerase binds Makes new DNA 5’ - 3’ Same direction as opening of helix Made continuously
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Replication
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Replication Lagging strand 5’ end of template Can’t be made continuously as direction is wrong RNA primer New DNA made 5’ 3’ Opposite direction of replication Discontinuous Okazaki fragments Ligase closes gaps
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This note was uploaded on 12/28/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Nucleic Acid Chemistry - Nucleic Acid Chemistry Where the...

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