Protein Structure

Protein Structure - Protein Structure (Campbell text...

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Unformatted text preview: Protein Structure (Campbell text chapters 4 and 5) (shape is everything) Why study structure? Structure helps us understand function Many disorders are due to aberrant protein structure Sickle cell anemia Can aid in design of therapeutics Disruption of structure causes disruption of function denaturation Native Structure The normal structure found in an organism Functional structure Human Insulin Prosthetic Groups Non-amino acid molecule that is necessary for the protein to function Ex: heme in hemoglobin Mostly an organic molecule Often contain metal ions Stabilization of Protein Structure H-bonds Backbone Side chain Disulfides Electrostatic Nonpolar forces Driving of protein folding What provides the energy? Stuff gets moved pretty far Requires energy Driven by entropy increase of solvent Levels of Protein Structure Primary Secondary Supersecondary Tertiary quaternary Primary Structure Amino acid sequence Read amino to carboxyl Below is the sequence for insulin malwmrllpl lallalwgpd paaafvnqhl cgshlvealy...
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This note was uploaded on 12/28/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Protein Structure - Protein Structure (Campbell text...

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