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Protein Structure

Protein Structure - Protein Structure(Campbell text...

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Unformatted text preview: Protein Structure (Campbell text chapters 4 and 5) (shape is everything) Why study structure? • Structure helps us understand function • Many disorders are due to aberrant protein structure – Sickle cell anemia – Can aid in design of therapeutics • Disruption of structure causes disruption of function – denaturation Native Structure • The normal structure found in an organism • Functional structure – Human Insulin Prosthetic Groups Non-amino acid molecule that is necessary for the protein to function • Ex: heme in hemoglobin • Mostly an organic molecule – Often contain metal ions Stabilization of Protein Structure • H-bonds – Backbone – Side chain • Disulfides • Electrostatic • Nonpolar forces Driving of protein folding • What provides the energy? – Stuff gets moved pretty far Requires energy Driven by entropy increase of solvent Levels of Protein Structure • Primary • Secondary – Supersecondary • Tertiary • quaternary Primary Structure • Amino acid sequence – Read amino to carboxyl – Below is the sequence for insulin malwmrllpl lallalwgpd paaafvnqhl cgshlvealy...
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Protein Structure - Protein Structure(Campbell text...

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