Allergy-tx-slides-050216

Allergy-tx-slides-050216 - Immunology and immunotherapy in...

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Immunology and immunotherapy in allergic disease Jing Shen , M. D. Matthew Ryan, M. D.
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Allergy Allergic reaction is an exaggerated or inappropriate immune reaction and causes damage to the host Hypersensitivity: Type I: anaphylactic reaction: mediated by IgE antibodies, which trigger the mast cells and basophils to release pharmacologically active agents. Type II: cytotoxic reaction: IgM or IgG antibodies bind to antigen on the surface of cells and activate complement cascade.
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Hypersensitivity Type III: Immune complex reaction: complexes of antigen and IgM or IgG antibodies accumulate in the circulation or in tissue and activate the complement cascade. Granulocytes are attracted to the site of activation and release lytic enzymes Type IV: cell-mediated immunity reaction: mediated by T cells, which release cytokines upon activation to cause accumulation and activation of macrophages.
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Immunology review Antigen presenting cell T lymphocytes B lymphocytes IgE antibody Mast cells Eosinophil
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Antigen presenting cells Function: take up antigen, process and present antigen to T cells Including: macrophage, dendritic cell, B lymphocyte and activated T lymphocyte Major histocompatibility complex (MHC) class I: binds with CD8+ T cell only Class II: binds with CD4+ T cell only
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From: Immunology a short course, 1996 figure10.5
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From: Immunology a short course, 1996 figure 11.1
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CD4+ T lymphocyte 2 subsets based on distinct cytokines produced Th1: produce IL-2, IL-12, interferon (IFN)- gamma activate CD8+ T cell, natural killer cells, and macrophage Elimination of intracellular pathogen, facilitate delayed hypersensitivity
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CD4+ T lymphocyte Th2: produce IL-4, IL-5, IL-10 activate B cells and switch antibody synthesis to IgE mediate allergic inflammation preferentially activate Th2 cells leading to development of allergic disease Th1 and Th2 inhibit the development of each other
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From: kay: New England J of Medicine Vol 344(1). Jan 4, 2001. 30-37
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Cytokines IL-4: Produced by Th2 and mast cell Growth factor for B cells and Th2 cells Promotes IgE production Inhibits Th1 cell IL-5: Produced by Th2 cell Growth and differentiation factor for eosinophil IL-2: Produced exclusively by T cell: Th0 and Th1 T cell growth factor IFN- gamma: Produced by Th1 cell Activates NK cells, macrophages, and killer cells, Inhibits Th2 cell Induce expression of MHC class II on many cell types
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B lymphocyte and IgE antibodies B lymphocyte needs 2 signals to mature to IgE
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Allergy-tx-slides-050216 - Immunology and immunotherapy in...

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