Olfactory-slides-2003-1126

Olfactory-slides-2003-1126 - Olfactory Dysfunction and...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Olfactory Dysfunction and Disorders Jing Shen, M.D. Matthew Ryan, M.D.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Introduction Importance of olfaction: Determines  the flavor of foods and beverages Early  warning  system for detection of environmental  hazards. Prevalence: 2 million Americans  At least 1% population under age of 65 and  well over 50% over age 65
Background image of page 2
Anatomy and Physiology 3 neural systems CN I: main olfactory system Mediates odor sensation CN V: trigeminal somatosensory system Mediates somatosensory sensation  CN 0: nervus terminalis Unknown exact function in humans
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Olfactory Epithelium Pseudostratified columnar epithelium Located in the upper recesses of the  nasal chambers Cribriform plate, superior turbinate, superior  septum, section of middle turbinate Harbors sensory receptors of CN I
Background image of page 4
Cell Types in Olfactory Epithelium Bipolar sensory receptor neurons 6,000,000 cells in adults Olfactory receptors located on the ciliated  dendritic ends Axons form 40 bundles as olfactory fila Microvillar cells Near the surface of epithelium Exact function unknown
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cell Types Supporting cells Insulate receptor cells Regulate mucus composition Deactivate odorants Protect epithelium from foreign agents Globose basal cells Horizontal basal cells Cells lining Bowman’s gland
Background image of page 6
Olfactory Neuroepithelium
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Olfactory Sensory Receptor Neuron
Background image of page 8
Receptors Located on cilia of receptor cells 1000 classes - 1% of all expressed  genes Linked to guanine nucleotide binding  protein->activate adenylate cyclase->  cAMP->depolarization One cell- one type of receptor
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Olfactory Bulb Located on top of cribriform plate at the  base of frontal lobe Complex processing center Receives receptor cell axons Olfactory tract projects to olfactory cortex  Frontal lobe, temporal lobe, thalamus,  hypothalamus
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/28/2011 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

Page1 / 33

Olfactory-slides-2003-1126 - Olfactory Dysfunction and...

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online