DNA160-page9 - and T-A This takes place on both sides of...

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DNA: Structure and Replication - 9 A few details about the process: Prior to cell division, the enzyme, DNA helicase, facilitates the unwinding of the double-stranded DNA molecule forming replication bubbles in the DNA molecule. Replication forks are formed at the origin of each bubble. New DNA is replicated behind each fork as it progresses along the DNA molecule in both directions from the origin. In eukaryotic organisms, there are many, many replication units involved in the replication of DNA on each chromosome. Each replication unit forms a replication fork at its "origin". As DNA replication progresses in both directions from the origin, replication units join other units when they meet an adjacent replication forks. Each of the two strands of the DNA molecule in the fork serves as a template for the attachment of its complement nucleotides (A-T, C-G, G-C
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Unformatted text preview: and T-A). This takes place on both sides of the replication forks simultaneously, but in opposite directions. • The enzyme, DNA polymerase, promotes the synthesis of the new DNA strands, by recognizing the appropriate complementary base needed and by bonding appropriate daughter nucleotides to the growing DNA molecule. • DNA polymerase has two limitations: 1. DNA polymerase cannot add nucleotides until there is a double-stranded starter. It can read the single chain template, but can't bond the nucleotides for the new strand for replication with just the single-stranded template. 2. DNA polymerase can only work in one direction and the double-stranded DNA has two directions at each replication fork....
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