Unformatted text preview: DNA polymerase sliding rings. • To do so, the lagging strand must be unwound a greater distance before replication can start, and will be looped to provide the needed orientation for DNA polymerase. New DNA polymerase enzyme molecules have to attach and work on small portions of the lagging strand of the unzipped DNA molecule. Once segments of the lagging strand, called Okazaki fragments, are synthesized, the RNA primer nucleotides are removed and DNA polymerase replaces them with DNA nucleotides. The enzyme, DNA ligase, links the short pieces of the lagging side together. Note: Each Okazaki fragment must be initiated by a RNA primer....
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- Spring '10