Energy160-page12 - active site are called competitive...

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Energy Flow in Cells - 12 Feedback Inhibition Many enzymes are regulated by feedback mechanisms that tell the enzyme that its job is finished. Often the product of the reaction serves as this control. When enough product is formed, some of the product blocks the enzyme's activity, stopping the reaction. As the product is used up, its block of the enzyme is removed, and the enzyme can be active again. This process is called feedback inhibition. Competitive Inhibition Some enzyme inhibitors compete with the substrate for the enzyme's active site and wind up blocking the active site since they do not undergo a chemical reaction and get released from the enzyme. Substances that compete for the enzyme's
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Unformatted text preview: active site are called competitive inhibitors. For example, both methanol and ethanol for the active site on the enzyme alcohol dehydrogenase. Substances that bind to the enzyme at some other place changing its shape so it can no longer function effectively are called non-competitive inhibitors. Allosteric inhibitors are non-competitive inhibitors. A number of poisons block enzyme activity in this way. Many pesticides block essential nervous system enzymes. Mercury inhibits the function of many enzymes, partly by blocking the attachment of the needed cofactor....
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This note was uploaded on 12/29/2011 for the course BIO 151 taught by Professor Edwards during the Spring '10 term at SUNY Stony Brook.

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