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Unformatted text preview: associated with mutations in genes that regulate cell division. Such genes that normally control cell division but when mutated have the potential to induce cancer are called oncogenes. They are often called proto-oncogenes when functioning normally. Oncogenes also include genes that normally suppress tumor formation by monitoring DNA and cell division to ensure that all is well. The P53 tumor suppressor gene is one such gene mentioned earlier. P53 is a transcription factor for genes that keep a cell's DNA repaired and genes that delay the cell's rate of cell division so that there is time for DNA repair. If the cell is in bad shape, P53 activates cell suicide genes to prevent the harmful mutations from being passed on. Such cell death is called apoptosis, and is genetically programmed. When p53 is defective or missing, cancers are more likely because DNA damage isn't caught and repaired....
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- Spring '10