HumanInheritance160-page5 - Some Sex-Linked Human Disorders...

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Human Inheritance Patterns - 5 Sex-Linked Recessive Problems Sex-linked human disorders are caused by non-functioning alleles on the X chromosome. Sex-linked human disorders disproportionately appear in males, who inherit the non-functioning allele from a carrier (heterozygous) mother who does not exhibit the symptoms of the disorder. Fathers pass the allele to their daughters, who, if they inherit a normal allele from the mother will be carriers who do not exhibit symptoms. Females must inherit the non-functioning allele from both parents to have symptoms of the disorder. In a similar fashion, sons cannot inherit the allele from their father, because they inherit the Y chromosome from their father.
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Unformatted text preview: Some Sex-Linked Human Disorders • Hemophilia • Hemophilia is caused by the inability to produce a critical blood-clotting factor. • Hemophilia is treated by supplying the affected individuals with the clotting factor. If not treated, hemophilia is usually fatal. • Duchenne Muscular Dystrophy • One of the forms of muscle degeneration • Fragile X • A nucleotide repeat disorder that causes mental impairment • Red-green colorblindness • Androgen insensitivity • Males do not respond in development to androgen signals resulting in sterility and some "female" traits....
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