HumanInheritance160-page6 - In general, we call this...

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Human Inheritance Patterns - 6 Changes in Chromosome Number and Inheritance It is fairly easy to observe our 46 human chromosomes and their shapes, because we can obtain a karyotype, or chromosome display during the metaphase stage of cell division. This allows us to see distinct chromosomes, and detect patterns that are not typical. Aneuploidy For reasons not understood, occasionally, a homologous chromosome pair will fail to separate during meiosis, resulting in an egg or sperm with one more or one less than the normal complement of chromosomes (trisomy or monosomy).
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Unformatted text preview: In general, we call this non-disjunction or aneuploidy. Most often, a non-disjunction results in a gamete, or if there is successful fertilization, an embryo that does not survive. In some cases, however, some gametes or embryos do survive, producing individuals with abnormal chromosome numbers. Most non-disjunctions have serious genetic consequences. A non-disjunction can affect either the sex-determining chromosomes or autosomes. We will mention a few human examples....
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