IMG_0004_NEW_0006

IMG_0004_NEW_0006 - 1 Cell Structure and Function

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Cell Structure and Function 1 Yourpredictionwasbasedonthemolecularweightsofthesecompounds.Looknowat thetableonPage8.Twoextracolumnshavebeenaddedtothetableofpagel.These columns are the permeabiliry coefficient (p) and the distibution coeffrcient' The permeabilitycoeffrcientmeasurestheeasewithwhichacompoundpenetratesthecell membrane.AhigherPvaluemeanstt,,"o,npoundenterstheccllmoreeasilythan anothercompoundwithalower,P,value.Thedistibutioncoefficientcomparesthe solubilityofthecompoundinoilwiththatinwater.Acompoundwithahigher distribution coefficientis more soluble in o'and less soruble in water than a compound withalowervalue.Usingthisinformation,studythetableandanswerquestions3,4and 5. Therelationshipbetweenpermeabilitycoefficientanddistributioncoefficient indicatesthatoemoresolubleacompoundisinoil(i.e.thelargerthedistribution coefrrcient),themoreeasilyitpenetratesthecetlmembrane(i.e.thehigherthe permeabilitycocfficientorPvalue).Therefore,thecompoundswithhighermolecular weightsactuallyenteredthecellfasterthanthecompoundswithlowermolecular
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This note was uploaded on 12/29/2011 for the course MBB 222 taught by Professor Briscoe during the Fall '10 term at Simon Fraser.

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