100711Lec1-2

100711Lec1-2 - Prof. Patrick Daugherty TA: Serra...

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Unformatted text preview: Prof. Patrick Daugherty TA: Serra Elliot 109C topics that you should already know •  Carbohydrates & lipids •  Amino acids, pepBdes, and proteins •  Mechanisms of catalysis •  Nucleosides, nucleoBdes, and nucleic acids Old view: Chemistry and physics are the founda9onal sciences for Chemical Engineering. New view: Biology is a founda9on for Chemical Engineering on equal foo9ng with chemistry and physics. Biological Engineering & Biotechnology •  AlternaBve Energy; Biofuels producBon: ethanol, cellulosic conversions, sugar to alkanes •  Metabolic engineering; (e.g., arBmisinin) •  Systems biology; drug delivery (e.g. insulin), fuels •  SyntheBc biology; designer biological systems •  Drug development and producBon Chemical Engineers are uniquely equipped to address these problems, using kinetics, thermodynamics and transport phenomena. Novel Thermostable, Highly Ac9ve Cellulases by Non ­Con9nuous SCHEMA Recombina9on 2011 Draper Prize Winners Frances Arnold (Caltech ChE) Willem Stemmer “The Nobel prize of engineering.” One of the active chimeric enzymes is half prokaryote (red) and half eukaryote (green). Top: 2D parental sequence alignment showing pieces that come from each parent. Bottom: The sequences from each parent are contiguous in 3D but not 2D. Chemical Engineer Jay Keasling awarded a $42 million grant from the Bill & Melinda Gates Founda9on, to produce artemisinic acid, a prescursor to the an9 ­malarial drug artemisinin. Jay Keasling UCB ChE •  Tissue engineering •  Device engineering: Drug pumps, arBficial organs •  Drug delivery Chemical Engineers are uniquely equipped to address these problems, using kinetics, thermodynamics and transport. Glucose concentration Control algorithms enable automated delivery of insulin to DiabeBcs Frank Doyle UCSB ChE Delivery of therapeu9cs from blood vessels to tumors is influenced by… Transport; convec(on, diffusion Kine4cs; binding, internaliza(on, degrada(on Tumor Rakesh Jain ChE Harvard Dane WiZrup ChE MIT Chemical Engineers have a unique skill set to formulate and solve difficult problems drug delivery to tumor [AB] A D P U A What is [AB](t) =?? A k B KineBcs and transport are criBcal to drug metabolism Advanced Drug Delivery Systems Polymers + Drugs Robert Langer (MIT) Draper Prize 2002 Biological Engineering •  Tissue engineering •  Device engineering: Drug pumps, arBficial organs •  Drug delivery Advanced Study •  Graduate School •  Law •  Medicine Chemical Engineers are uniquely equipped to address these problems, using kinetics, thermodynamics and transport. Biologically assembled materials A baZery built on viruses Angela Belcher MIT ScienBst of the Year TIME McCarther FoundaBon Award Biochemical Engineering •  Drugs & anBbioBcs •  Foods •  Food addiBves •  Beverages •  Special Chemicals Fed Batch Mass Balances Cell Substrate Product Total Mass Use Monod Equation for Specific Growth Rate (assumes constant density) What organism from the hot springs of Yellowstone Park transformed biotechnology, and led to a Nobel prize? mycoplasma Genomes big or small…. 477 genes Prokaryote Morphology Escherichia coli The applica9ons of baker’s yeast range from ethanol Produc9on to the discovery of therapeu9c human an9bodies Fungi Aspergillus niger Aspergillus nidulans Tricoderma harzianum Cell Membranes Genome size does not predict organism complexity Mice remain a cri9cally important model organism To beXer understand human disease Other widely used model organisms include… ...
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This note was uploaded on 12/29/2011 for the course CHE 170 taught by Professor Ceweb during the Fall '10 term at UCSB.

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