101311enzy-struc-ex - Enzyme catalysis and inhibi1on:...

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Unformatted text preview: Enzyme catalysis and inhibi1on: Thrombin and HIV protease •  Enzymes can be inhibited by: –  Covalent suicide inhibitors –  Tight binding inhibitors •  Ac:ve site binding •  Exosite binding •  Ac:ve site and exosite binding •  Three types of inhibi:on mechanisms: –  Compe::ve inhibi:on –  Non ­compe::ve –  Mixed inhibi:on Thrombin ­hirudin complex HIV protease in complex with pep:de inhibitor ...
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This note was uploaded on 12/29/2011 for the course CHE 170 taught by Professor Ceweb during the Fall '10 term at UCSB.

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