101711-lecture10-18-11

101711-lecture10-18-11 - Protein Structure and Function ChE...

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Protein Structure and Function ChE 170 Lecture 10/18/11
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Protein Function is Dictated by its Structure Enzyme activity can depend on structural conformation Unique binding sites in antibodies dictate the specific ligand to which the antibody binds Pinkas et al PLoS Biol (2007) Active State
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Herceptin and HER2 Cho, H.-S. et al. Nature (2003). PDB ID: 1N8Z
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So Why Do We Care about Protein Structure/Function? Discussion
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Importance of Understanding Protein Binding Interactions Antibodies and the immune response Binding of agonistic ligands to cell surface receptors – GPCR’s such as the AT 1 receptor Engineering therapeutic drugs Specificity and side effects Affinity affects transport Wittrup’s model + + ) ) / ] ([ ) ] ([ β α ε B A Ag K Ab D R D surf ) / ] ([ ) ] ([ Ag k K Ab D R e D surf + Thurber, Schmidt, & Wittrup. Trends in Pharmacological Sciences (2007).
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Destabilizing conditions
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This note was uploaded on 12/29/2011 for the course CHE 170 taught by Professor Ceweb during the Fall '10 term at UCSB.

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101711-lecture10-18-11 - Protein Structure and Function ChE...

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