FDoyle

FDoyle - 11/28/2010 TrendsinScientificInvestigation...

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11/28/2010 1 ChE 170 Lecture Notes © Francis J. Doyle III, Fall 2010 Trends in Scientific Investigation Genes Proteins Cell Organ Organism Integrative Complexity Systems Analysis 20 th Century Genomics 20 th Century Biomedical Sciences 21 st Century Genomics Proteomics Molecular biophysics Bioinformatics Structural Biology 21 st Century Integrated systems biology Dynamic systems modeling Reductionism [adapted from (J. Weiss, 2003)] ChE 170 Lecture Notes © Francis J. Doyle III, Fall 2010 What is “Systems Biology”? [WTEC Benchmark Study (2005): M. Cassman, A. Arkin, F. Doyle, F. Katagiri, D. Lauffenburger, C. Stokes] [also: Nature , Dec 22, 2005] Primary Definition : The understanding of biological network behavior through the application of modeling and simulation, tightly linked to experiment Related Ideas Identification and validation of networks Creation of appropriate datasets Development of tools for data acquisition and software Motivation: Phenotype is governed by the behavior of networks , rather than the operation of single genes. Understanding the dynamics of even the simplest biological networks requires the application of modeling and simulation.
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11/28/2010 2 ChE 170 Lecture Notes © Francis J. Doyle III, Fall 2010 A Simple Network ChE 170 Lecture Notes © Francis J. Doyle III, Fall 2010 Central Dogma and Levels of Control [Alberts et al ., Essential Cell Biology , 1998]
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11/28/2010 3 Circadian Rhythms Circadian rhythms = self-sustained biological rhythms characterized by a free-running period of about 24h ( circa diem ) Circadian rhythms characteristics: • General – bacteria, fungi, plants, flies, fish, mice, humans, etc.
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This note was uploaded on 12/29/2011 for the course CHE 170 taught by Professor Ceweb during the Fall '10 term at UCSB.

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FDoyle - 11/28/2010 TrendsinScientificInvestigation...

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