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Unformatted text preview: (maximum Phi ). Sequence space Error threshold If the mutation rate is to high, the quasispecies cannot maintain genetic information. Advantageous mutants disappear. Error threshold f f 2 2 2 1 1 2 1 1 1 1 ) 1 ( Mutants Wildtype x x f Q x f x x Q x f x+== & & 2 1 if survives Wildtype f Q f Error threshold implies a maximum genome length p L / 1 < mutation rate per base genome length Error threshold Adaptation is only possible if the mutation rate is below a certain threshold. Localization L p / 1 < Applications of quasispecies theory n origin of life n in vitro evolution n viruses n bacteria n cancer Extensions n More complicated mutation operator (insertion, deletion, recombination, etc) n Stochastic formulation (finite population)...
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 Fall '09

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