212_spring_2005_heme synthesis

212_spring_2005_heme - Pathophysiology of Heme Synthesis Beth A Bouchard BIOC 212 Biochemistry of Human Disease Spring 2005 HEME-CONTAINING

Info iconThis preview shows pages 1–13. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Pathophysiology of Heme Synthesis Beth A. Bouchard BIOC 212: Biochemistry of Human Disease Spring 2005 HEME-CONTAINING PROTEINS • Hemoglobin • Myoglobin • Cytochromes • Catalase • Some peroxidases Iron Utilization STRUCTURE OF HEME • Ferrous iron (Fe 2+ ) • Protoporphyrin IX: contains 4 pyrrole rings linked together by methenyl bridges Heme 8 8 Succinyl CoA Glycine** HEME SYNTHESIS ** Amino acid (building blocks of protein) synthesized in your body Heme synthesis HEME SYNTHESIS HEME SYNTHESIS: Red blood cells • 85% of total heme synthesis occurs in red blood cells (RBC) • Ceases when RBC’s mature • Heme stimulates protein synthesis in reticulocytes Synthesis is regulated at the level of the enzymes ferrochelatase* and porphobilinogen deaminase** ** * HEME SYNTHESIS: Liver • The liver is the main non-RBC source of heme synthesis • Heme produced in the liver is used mainly for the synthesis of the cytochrome P 450 class of enzymes that are involved in detoxification Regulated at level of ALA synthase: Formation of 5-ALA is the rate- limiting step in heme synthesis in the liver Formation of 5-aminolevulinate (5-ALA) 5-ALA • 5-ALA is formed in the mitochondria and transported to the cytoplasm Regulation of ALA Synthase...
View Full Document

This note was uploaded on 01/02/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

Page1 / 21

212_spring_2005_heme - Pathophysiology of Heme Synthesis Beth A Bouchard BIOC 212 Biochemistry of Human Disease Spring 2005 HEME-CONTAINING

This preview shows document pages 1 - 13. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online