3850S1_03_FDA-WILKIN

3850S1_03_FDA-WILKIN - URTICARIA: Overview and OTC...

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Jonathan Wilkin, M.D. Director, Division of Dermatologic and Dental Drug Products, FDA URTICARIA: Overview and OTC Considerations April 22, 2002
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10 HEURISTIC SUBDIVISIONS 1.Acute urticaria - less than 6 weeks; history implicates cause in approx. 50%; difficult to study in clinical trials; good prognosis. 2.Chronic urticaria - greater than 6 weeks; workup indicated; easier to study; often persistent. 3.Chronic idiopathic urticaria - subset of chronic urticaria in which workup fails to pinpoint cause; diagnosis by exclusion; not homogeneous.
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12 OBSERVATIONS 1.Urticaria is not a single disease, but a REACTION PATTERN mediated by HISTAMINE release in the superficial skin. 2.Acute urticaria and chronic urticaria are not single diseases, but are useful heuristic distinctions directing clinical decisions. 3.Most types of urticaria will respond to an antihistamine found safe and effective in patients with Chronic Idiopathic Urticaria.
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13 Urticaria Requiring a Physician
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3850S1_03_FDA-WILKIN - URTICARIA: Overview and OTC...

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