930528-1 - Cutaneous Autoimmune Blistering Disease ~...

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Cutaneous Autoimmune Blistering Disease ~ Pathology Case Review ~2004, March/Aprial
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Cutaneous blister Result of significant spongiosis, balloning degeneration, basal vacuolopathy, inherited disorder or autoimmune destruction Histology, DIF and clinical history to arrive at the correct diagnosis
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Case 1 24 y/o black woman with tense 2-3 cm fluid-filled blister on the upper extremity, joint pain and swelling Hx of SLE progress to involve the forehead and lower extremity LM: subepidermal blister with a dense neutrophilic infiltrate
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Case 1 DIF: linear Ig G, IgA and IgM deposition along the BM IIF: deposition along the floor of the skin
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Case 1 Beyond the mechanism of disruption, the levels of separation and the type of inflammatory responses help to further characterize the process Confirmation of autoantibody deposition: DIF, IIF, immunoblot, immunoprecepitation Immnoelerctorn microscopy Salt split skin : subepidermal blistering dx
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Porphyria cutanea tarda(PCT) Sun exposed sites
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This note was uploaded on 01/02/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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930528-1 - Cutaneous Autoimmune Blistering Disease ~...

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