allergic_skin 9.14.37 PM

allergic_skin 9.14.37 PM - Introduction: Urticaria and...

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Introduction: Urticaria and Angioedema Urticaria Angioedema
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Etiology of Urticarial Reactions: Allergic Triggers Acute Urticaria Drugs Foods Food additives Viral infections hepatitis A, B, C Epstein-Barr virus Insect bites and stings Contactants and inhalants (includes animal dander and latex) Chronic Urticaria Physical factors cold heat dermatographic pressure solar Idiopathic
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The Pathogenesis of Chronic Urticaria: Cellular Mediators
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Histamine as a Mast Cell Mediator
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Role of Mast Cells in Chronic Urticaria: Lower Threshold for Histamine Release Release threshold decreased by: Cytokines & chemokines in the cutaneous microenvironment Antigen exposure Histamine-releasing factor Autoantibody Psychological factors Release threshold increased by : Corticosteroids Antihistamines Cromolyn (in vitro) Cutaneous mass cell
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An Autoimmune Basis for Chronic Idiopathic Urticaria: Antibodies to IgE
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Initial Workup of Urticaria Patient history Sinusitis Arthritis Thyroid disease Cutaneous fungal infections Urinary tract symptoms Upper respiratory tract infection (particularly important in children) Travel history (parasitic infection) Sore throat Epstein-Barr virus, infectious mononucleosis Insect stings Foods Recent transfusions with blood products (hepatitis) Recent initiation of drugs Physical exam Skin Eyes Ears Throat Lymph nodes Feet Lungs Joints Abdomen
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This note was uploaded on 01/02/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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allergic_skin 9.14.37 PM - Introduction: Urticaria and...

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