Cutaneous-Malignancy

Cutaneous-Malignancy - Cutaneous Malignancy Robert H....

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Cutaneous Malignancy Robert H. Stroud, M.D. Anna M. Pou, M.D. 9 February 2000
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Epidemiology Most common human cancer 600,000 to 800,000 cases per year in U.S. Male:Female 2-3:1 80% arise in head and neck SCCa over 60 years old BCCa over 40 years old
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Etiology Ultraviolet radiation ethnicity ionizing radiation exposure chemical exposure - arsenic burns, scarring immunosuppression
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Syndromes Xeroderma pigmentosum nevoid basal cell syndrome albinism epidermodysplastic verrucoformis epidermolysis bullosa dystrophica dyskeratosis congenital
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Skin Largest organ major functions protection sensation thermoregulation metabolic
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Skin structure Epidermis dermis hypodermis epidermal  appendages
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Skin Histology Stratum corneum stratum lucidum stratum granulosum stratum spinosum stratum basale
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Actinic Keratosis Most common progress to  malignancy in 5-20% cryotherapy, shave  excision, 5-FU, TCA
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Actinic Keratosis
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Keratoacanthoma Solitary or multiple rapid growth 1 to 2.5 cm ulcer with keratinous  material spontaneous  resolution observe, 5-FU, Mohs'
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Keratoacanthoma
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Bowen’s Disease Carcinoma in situ erythematous plaque irregular borders non-exposed areas  with arsenic exposure
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Bowen’s Disease
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Basal Cell Carcinoma Raised, with pearly  border prominent  vasculature ulceration nodular most  common
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Pigmented Basal Cell Produce brown  pigment often mistaken for  melanoma behave similar to  nodular
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Superficial Basal Cell Scaly patches irregular borders extremities, less  common in head and  neck
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This note was uploaded on 01/02/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Cutaneous-Malignancy - Cutaneous Malignancy Robert H....

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